{"id":380,"date":"2022-02-09T10:59:45","date_gmt":"2022-02-09T10:59:45","guid":{"rendered":"https:\/\/new.maciasnmr.net\/?page_id=380"},"modified":"2025-01-28T11:27:09","modified_gmt":"2025-01-28T09:27:09","slug":"projects","status":"publish","type":"page","link":"https:\/\/maciasnmr.net\/?page_id=380","title":{"rendered":"Highlights"},"content":{"rendered":"\n
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Scientific contributions<\/h2>\n\n\n\n
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  1. WW-domains<\/strong>, protein signaling scaffolds and model systems of folding and amyloid formation. (Nature 1996<\/a>, Nature Structural & Molecular Biology 2000<\/a>, PNAS 2001<\/a>, 2014<\/a>, 2015<\/a>, JACS Au 2024<\/a>). <\/li>\n\n\n\n
  2. Defined a phosphorylation-dependent mechanism that labels SMADs<\/strong>, first for activation and then for degradation (Cell 2009<\/a>, Mol. Cell 2009<\/a>, Genes and Dev, 2011<\/a>, Structure 2012<\/a>).<\/li>\n\n\n\n
  3. Identified novel DNA motifs for SMAD proteins (Nature Communications, 2017<\/a>).<\/li>\n\n\n\n
  4. DNA recognition by the pioneer<\/strong>  maternal pioneer factor FoxH1<\/strong> (Nature Communications, 2022<\/a>)<\/li>\n\n\n\n
  5. Determined the molecular basis for distinct roles of SMAD2 and SMAD3 <\/strong>in the regulation of progenitor differentiation genes. This result challenges an erroneous view that had prevailed in the field for two decades that SMAD2 does not interact with DNA (Genes and Dev, 2019<\/a>).<\/li>\n\n\n\n
  6. Elucidated the rules that define the different composition of SMAD complexes in BMP and TGF\u03b2 pathways (Computational and Structural Biotechnology Journal 2021<\/a>).<\/li>\n\n\n\n
  7. Characterized the conformational landscape of full-length SMAD proteins<\/strong> using an integrative approach (Computational and Structural Biotechnology Journal 2021<\/a>).<\/li>\n\n\n\n
  8. TGF-\u03b2 and RAS jointly unmask primed enhancers to drive metastasis. Role of RREB1 and SMAD4 in chromatin remodeling (Cell, 2024<\/a>)<\/li>\n\n\n\n
  9. Peptide analogues with therapeutic properties (ChemBioChem 2011<\/a>, Angewandte Chemie 2012<\/a>, Scientific reports 2016<\/a>, ACS omega 2020<\/a>, Nature Communications 2021<\/a>, CSBJ 2022<\/a>, Communications Chemistry 2023<\/a> ).<\/li>\n\n\n\n
  10. First description of a closed conformation in p38\u03b1<\/strong> that modulates its kinase activity and is regulated by redox changes in the cell. Complex structures <\/strong>with 2 compounds (Nature Communications 2023 (I)<\/a>, Nature Communications 2023 (II)<\/a>)<\/li>\n\n\n\n
  11. Compounds that interact with SMAD proteins<\/strong> and prevent the formation of SMAD complexes.<\/li>\n\n\n\n
  12. Identification of markers for recurrence in Endometrial cancer<\/strong> using machine learning.<\/li>\n<\/ol>\n\n\n\n

    Last five years highlights<\/h2>\n\n\n\n