Here you can download the software developed at our laboratory.
A program that is agile and allows to analyze a very high number of curves in a very short time. The program finds wells for which dTm with respect the reference is higher than a given threshold. Then allows the user to validate the Tm with the minimum number of clicks. The program has been tested in Mac OSX and Windows, but any modern OS with python3 and a web browser should be able to run it.
You can download it here: https://github.com/maciaslab/htsdsf_explorer
If you use this software in a scientific publication, please cite:
HTSDSF Explorer, A Novel Tool to Analyze High-throughput DSF Screenings Pau Martin-Malpartida, Emil Hausvik, Jarl Underhaug, Carles Torner, Aurora Martinez, Maria J Macias Journal of Molecular Biology, 2021, 167372, doi:10.1016/j.jmb.2021.167372.
A set of python scripts to download and manipulate genomes and bed files. Can also be used to generate bed files containing any given motif, download motif descriptions from jaspar, and analyze motif number and inter-motif distances for user defined parts of any genome.
You can download it here: https://github.com/maciaslab/csutil
This web page is a companion to the review entitled Structural determinants of SMAD Function in TGF-β Signaling, by Maria J. Macias, Pau Martin-Malpartida and Joan Massagué; and published in Trends in Biochemical Sciences. It can be accessed here.